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inhibin alpha chain (INHA)
Function: alpha chain of inhibin
Structure:
- member of superfamily of proteins that includes TGF-beta, mullerian inhibitory factor, & activins
Compartment: secreted
Expression:
- ovary - granulosa cells
- testis - Sertoli cells
- brain
- placenta
- adrenal cortex - zona reticularis & inner zona fasciculata
Pathology:
- found in adrenocortical tumors
- expressed in prostate epithelium of
a) benign prostatic hyperplasia
b) basal cell hyperplasia & in nonmalignant regions of high grade prostate cancer
Related
activin
mullerian-inhibiting factor; anti-mullerian hormone; AMH; mullerian-inhibiting substance; MIS (AMH, MIF)
transforming growth factor [TGF]-beta
General
glycoprotein
protein subunit
TGF-beta family protein
Properties
SIZE: entity length = 366 aa
MW = 40 kD
MOTIF: signal sequence {1-18}
peptide motif {61-62}
N-glycosylation site {N146}
peptide motif {232-233}
cysteine residue {C262}
MODIFICATION: cysteine residue {C328}
N-glycosylation site {N268}
cysteine residue {C291}
MODIFICATION: cysteine residue {C363}
cysteine residue {C295}
MODIFICATION: cysteine residue {C365}
N-glycosylation site {N302}
cysteine residue {C327}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C328}
MODIFICATION: cysteine residue {C262}
cysteine residue {C363}
MODIFICATION: cysteine residue {C291}
cysteine residue {C365}
MODIFICATION: cysteine residue {C295}
Database Correlations
OMIM 147380
UniProt P05111
Pfam PF00019
Entrez Gene 3623
Kegg hsa:3623
References
- UniProt :accession P05111
- Wikipedia; Note: inhibin entry
http://en.wikipedia.org/wiki/inhibin
- Matzuk et al
Alpha-inhibin is a tumour-suppressor gene with gonadal
specificity in mice.
Nature 360:313 1992
PMID: 1448148
Component-of
inhibin-B