carboxypeptidase N subunit 2 (carboxypeptidase N polypeptide 2, carboxypeptidase N 83 kD chain, carboxypeptidase N regulatory subunit, carboxypeptidase N large subunit, CPN2, ACBP)

Function: - 83 kD subunit binds & stabilizes catalytic subunit & keeps it in circulation - under some circumstances it may be an allosteric modifier of the catalytic subunit Structure: - contains 13 LRR repeats (leucine-rich repeats) - whether or not any Cys participate in intrachain bonds is unknown, but they do not form interchain disulfide bonds with the catalytic subunit Compartment: secreted

General

glycoprotein protein subunit

Properties

QUANTITY: 2 SIZE: entity length = 545 aa MW = 61 kD MOTIF: signal sequence {1-21} leucine-rich repeat SITE: 72-95 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N74} leucine-rich repeat SITE: 96-119 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N111} N-glycosylation site {N119} leucine-rich repeat SITE: 120-143 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 144-167 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 169-191 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 192-215 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 217-239 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N228} leucine-rich repeat SITE: 241-263 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 264-287 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N266} leucine-rich repeat SITE: 289-311 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 312-335 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 337-359 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N348} N-glycosylation site {N359} leucine-rich repeat SITE: 360-383 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N518}

Database Correlations

OMIM 603104 UniProt P22792 PFAM correlations Entrez Gene 1370 Kegg hsa:1370

References

UniProt :accession P22792