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profilin
Function:
- prevents premature polymerization of monomeric actin
- facilitates unidirectional growth of actin from + end;
- binds to PIP/PIP2
- phospholipid binding may reduce affinity for G-actin [2]
Interactions
molecular events
General
cytoskeletal protein
phosphoprotein
Properties
SIZE: MW = 15 kD
MOTIF: phosphorylation site
binding site
FOR-BINDING-OF: phosphatidylinositol-4-phosphate
References
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 886
- Stossel TP.
On the crawling of animal cells.
Science. 1993 May 21;260(5111):1086-94. Review.
PMID: 8493552
Component-of
molecular complex