beta-fodrin; spectrin beta chain, brain 1; spectrin, non-erythroid beta chain 1; beta-II spectrin; Fodrin beta chain (SPTBN1, SPTB2)

Function: - phosphorylated on Ser-8 (putative), Ser-10 & Ser-14 - isoform 2 is phosphorylated on Ser-8 & Ser-10 - the short form cannot bind to the axonal protein fodaxin - interacts with ANK2 Structure: - belongs to the spectrin family - contains 2 CH (calponin-homology) domains - contains 1 PH domain - contains 17 spectrin repeats Compartment: - cytoplasm, cytoskeleton - myofibril, sarcomere, M-band (putative) - colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes (putative) - isoform 2: - cell membrane - peripheral membrane protein; cytoplasmic side (putative) Alternative splicing: named isoforms=3; long, short Expression: - isoform 2 is present in brain, lung & kidney (at protein level)

Properties

SIZE: entity length = 2364 aa MW = 275 kD MOTIF: actin-binding site SITE: 1-275 FOR-BINDING-OF: F-actin MOTIF: calponin homology domain NAME: calponin homology domain SITE: 54-158 calponin homology domain NAME: calponin homology domain SITE: 173-275 spectrin repeat {276-384} spectrin repeat {385-498} spectrin repeat {499-608} spectrin repeat {609-714} spectrin repeat {715-819} spectrin repeat {820-925} spectrin repeat {926-1032} MOTIF: Thr phosphorylation site {T999} spectrin repeat {1033-1139} spectrin repeat {1140-1245} spectrin repeat {1246-1350} spectrin repeat {1351-1462} spectrin repeat {1463-1562} ANK2 interaction {1563-2093} MOTIF: spectrin repeat {1563-1668} spectrin repeat {1669-1775} spectrin repeat {1776-1881} Tyr phosphorylation site {Y1805} spectrin repeat {1882-1987} Ser phosphorylation site {S1918} spectrin repeat {1988-2133} MOTIF: Ser phosphorylation site {S2102} Ser phosphorylation site {S2115} Ser phosphorylation site {S2128} Ser phosphorylation site {S2138} Thr phosphorylation site {T2159} Ser phosphorylation site {S2160} Ser phosphorylation site {S2164} Ser phosphorylation site {S2165} Ser phosphorylation site {S2169} Thr phosphorylation site {T2187} Thr phosphorylation site {T2195} PH domain {2197-2307} Ser glycosylation site {S2324} Thr phosphorylation site {T2328} Ser phosphorylation site {S2341}

Database Correlations

OMIM 182790 UniProt Q01082 PFAM correlations Entrez Gene 6711 Kegg hsa:6711