alpha-fodrin; spectrin alpha chain, brain; spectrin, non-erythroid alpha chain; alpha-II spectrin; fodrin alpha chain (SPTAN1, SPTA2)

Function: - interacts with isoform 1 of ACP1 - interacts with calmodulin (CALM) Structure: - belongs to the spectrin family - contains 3 EF-hand domains - contains 1 SH3 domain - contains 23 spectrin repeats Compartment: - cytoplasm, cytoskeleton. cytoplasm, cell cortex Alternative splicing: named isoforms=3

Properties

SIZE: entity length = 2472 aa MW = 285 kD MOTIF: spectrin repeat {10-42} spectrin repeat {44-147} spectrin repeat {149-253} spectrin repeat {255-359} spectrin repeat {361-465} spectrin repeat {467-571} spectrin repeat {573-676} spectrin repeat {678-782} spectrin repeat {784-888} spectrin repeat {890-955} src homology 3 [SH3] domain SITE: 967-1026 Ser phosphorylation site {S1029} Ser phosphorylation site {S1031} spectrin repeat {1062-1089} spectrin repeat {1091-1161} peptide motif {1176-1177} MOTIF: Tyr phosphorylation site {Y1176} spectrin repeat {1208-1231} MOTIF: Ser phosphorylation site {S1217} spectrin repeat {1233-1337} MOTIF: Ser phosphorylation site {S1323} spectrin repeat {1339-1443} spectrin repeat {1445-1549} spectrin repeat {1551-1656} spectrin repeat {1658-1762} spectrin repeat {1764-1868} spectrin repeat {1870-1974} spectrin repeat {1976-2081} spectrin repeat {2091-2195} spectrin repeat {2205-2310} EF hand SITE: 2323-2358 MOTIF: Ca+2-binding site SITE: 2336-2347 EF hand SITE: 2366-2401 MOTIF: Ca+2-binding site SITE: 2379-2390 EF hand SITE: 2404-2439 MOTIF: Tyr phosphorylation site {Y2423}

Database Correlations

OMIM 182810 UniProt Q13813 PFAM correlations Entrez Gene 6709 Kegg hsa:6709