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enzymatic reaction
A chemical reaction catalyzed by an enzyme. An enzymatic reaction consists of substrate(s), enzyme & product(s). The enzyme is unchanged by the reaction.
Properties
GENERAL:
catalytic reaction
SPECIFIC:
biochemical ligation
sialylation
active transport
protein phosphorylation
proteolytic cleavage
template-directed reaction
ENZYME:
plasmin
COMPARTMENT: plasma
MOTIF: charge relay system
MOTIF: aspartate residue
histidine residue
serine residue
kringle domain
allosteric site
FOR-BINDING-OF: complement C1 inhibitor
STATE: active state
SUBSTRATE:
TGF-beta
CONFIGURATION: dimer
COMPARTMENT: extracellular compartment
STATE: Inactive
MOTIF: binding site
FOR-BINDING-OF: matrix protein
cysteine-rich region
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+7}
cysteine residue {X+6}
MODIFICATION: cysteine residue {X+50}
cysteine residue {X+7}
MODIFICATION: cysteine residue {X+0}
cysteine residue {X+26}
MODIFICATION: cysteine residue {X+70}
cysteine residue {X+29}
MODIFICATION: cysteine residue {X+72}
cysteine residue {X+49}
MODIFICATION: cysteine residue {X+49}
cysteine residue {X+50}
MODIFICATION: cysteine residue {X+6}
cysteine residue {X+70}
MODIFICATION: cysteine residue {X+26}
cysteine residue {X+72}
MODIFICATION: cysteine residue {X+29}
glutamine-rich region
MOTIF: glutamine residue (6)
SECRETED-BY: platelet
macrophage
monocyte
T-cell
endothelial cell
fibroblast
PRODUCT:
TGF-beta
CONFIGURATION: dimer
COMPARTMENT: extracellular compartment
STATE: active state
MOTIF: binding site
FOR-BINDING-OF: matrix protein
cysteine-rich region
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+7}
cysteine residue {X+6}
MODIFICATION: cysteine residue {X+50}
cysteine residue {X+7}
MODIFICATION: cysteine residue {X+0}
cysteine residue {X+26}
MODIFICATION: cysteine residue {X+70}
cysteine residue {X+29}
MODIFICATION: cysteine residue {X+72}
cysteine residue {X+49}
MODIFICATION: cysteine residue {X+49}
cysteine residue {X+50}
MODIFICATION: cysteine residue {X+6}
cysteine residue {X+70}
MODIFICATION: cysteine residue {X+26}
cysteine residue {X+72}
MODIFICATION: cysteine residue {X+29}
glutamine-rich region
MOTIF: glutamine residue (6)
SECRETED-BY: platelet
macrophage
monocyte
T-cell
endothelial cell
fibroblast
peptide
References
- Hajjar DP & Pomerantz KB
Signal transduction in atherosclerosis: integration of
cytokines and the eicosanoid network.
FASEB J 6:2933 1992
PMID: 1644257