platelet glycoprotein 1b

Function: - component of platelet vWF receptor GP-Ib-V-IX & thrombin - participates in the formation of platelet plugs by binding to the A1 domain of von Willebrand factor, which is already bound to the subendothelium - becomes exposed on the surface of platelets upon activation - forms complex with glycoprotein IX & glycoprotein V Structure: - heterodimer composed of GP-1b alpha & GP-1b beta, disulfide linked - GP-IX is complexed with the GP-1b heterodimer via a non covalent linkage

Related

glycoprotein-Ib-V-IX complex platelet von Willebrand factor; vWF; ristocetin cofactor; factor VIII related antigen; contains: von Willebrand antigen 2 (VWF, F8VWF)

General

adhesion receptor multisubunit protein

Properties

COMPARTMENT: plasma membrane CELL: platelet MOTIF: focal adhesion site transmembrane domain SUBUNITS: platelet glycoprotein Ib alpha chain MOTIF: signal sequence {1-16} cysteine residue {C20} MODIFICATION: cysteine residue {C33} cysteine residue {C33} MODIFICATION: cysteine residue {C20} N-glycosylation site {N37} leucine-rich repeat SITE: 70-92 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 93-117 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 119-138 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 139-162 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 164-186 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N175} leucine-rich repeat SITE: 188-210 MOTIF: leucine residue (SEVERAL) cysteine residue {C225} MODIFICATION: cysteine residue {C264} cysteine residue {C227} MODIFICATION: cysteine residue {C280} cysteine residue {C264} MODIFICATION: cysteine residue {C225} cysteine residue {C280} MODIFICATION: cysteine residue {C227} Tyr phosphorylation site {Y292} Tyr phosphorylation site {Y294} Tyr phosphorylation site {Y295} Thr glycosylation site {T308} threonine-rich region {345-456} MOTIF: threonine residue (SEVERAL) transmembrane domain {506-526} Ser phosphorylation site {S603} Ser phosphorylation site {S606} platelet glycoprotein Ib beta chain MOTIF: signal sequence {1-26} leucine-rich repeat SITE: 60-83 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N66} transmembrane domain {148-172} Ser phosphorylation site {S191} Thr phosphorylation site {T193}

References

Fibrinolysis, Thrombosis, & Hemostasis: Concepts, Perspectives, and Clinical Applications. S Sherry, Lea & Febiger, Philadelphia, 1992, pg 73

Components

CD42b; platelet glycoprotein Ib alpha chain; glycoprotein Ibalpha; GP-Ib alpha; GPIb-alpha; GPIbA; antigen CD42b-alpha; human platelet antigen 2; HPA-2 (GP1BA) CD42c; platelet glycoprotein Ib beta chain; GP-Ib beta; GPIb-beta; GPIbB; antigen CD42b-beta (GP1BB)