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enzymatic reaction
A chemical reaction catalyzed by an enzyme. An enzymatic reaction consists of substrate(s), enzyme & product(s). The enzyme is unchanged by the reaction.
Properties
GENERAL: catalytic reaction
SPECIFIC: biochemical ligation
sialylation
active transport
protein phosphorylation
proteolytic cleavage
template-directed reaction
ENZYME: plasmin
COMPARTMENT: plasma
MOTIF: charge relay system
MOTIF: aspartate residue
histidine residue
serine residue
kringle domain
allosteric site
FOR-BINDING-OF: complement C1 inhibitor
STATE: active state
SUBSTRATE: coagulation factor VIII
COMPARTMENT: plasma
MOTIF: signal sequence {1-19}
F5/8 type A 1 {20-348}
MOTIF: Plastocyanin-like 1 {20-198}
N-glycosylation site {N60}
cysteine residue {C172}
MODIFICATION: cysteine residue {C198}
cysteine residue {C198}
MODIFICATION: cysteine residue {C172}
Plastocyanin-like 2 {206-348}
N-glycosylation site {N258}
cysteine residue {C267}
MODIFICATION: cysteine residue {C348}
cysteine residue {C348}
MODIFICATION: cysteine residue {C267}
proteolytic site {391-392}
F5/8 type A 2 {399-730}
MOTIF: Plastocyanin-like 3 {399-573}
cysteine residue {C547}
MODIFICATION: cysteine residue {C573}
cysteine residue {C573}
MODIFICATION: cysteine residue {C547}
Plastocyanin-like 4 {583-730}
N-glycosylation site {N601}
cysteine residue {C649}
MODIFICATION: cysteine residue {C730}
cysteine residue {C730}
MODIFICATION: cysteine residue {C649}
proteolytic site {759-760}
B {760-1667}
MOTIF: N-glycosylation site {N776}
N-glycosylation site {N803}
N-glycosylation site {N847}
N-glycosylation site {N919}
N-glycosylation site {N962}
N-glycosylation site {N982}
N-glycosylation site {N1020}
N-glycosylation site {N1024}
N-glycosylation site {N1074}
N-glycosylation site {N1085}
N-glycosylation site {N1204}
N-glycosylation site {N1274}
N-glycosylation site {N1278}
N-glycosylation site {N1301}
N-glycosylation site {N1319}
proteolytic site {1332-1333}
N-glycosylation site {N1431}
N-glycosylation site {N1461}
proteolytic site {1667-1668}
proteolytic site {1708-1709}
F5/8 type A 3 {1713-2040}
MOTIF: Plastocyanin-like 5 {1713-1877}
N-glycosylation site {N1829}
cysteine residue {C1851}
MODIFICATION: cysteine residue {C1877}
cysteine residue {C1877}
MODIFICATION: cysteine residue {C1851}
Plastocyanin-like 6 {1887-2040}
cysteine residue {C1918}
MODIFICATION: cysteine residue {C1922}
cysteine residue {C1922}
MODIFICATION: cysteine residue {C1918}
coagulation factors 5/8 type C domain (FA58C) {2040-2188}
MOTIF: cysteine residue {C2040}
MODIFICATION: cysteine residue {C2188}
N-glycosylation site {N2137}
cysteine residue {C2188}
MODIFICATION: cysteine residue {C2040}
coagulation factors 5/8 type C domain (FA58C) {2193-2345}
MOTIF: cysteine residue {C2193}
MODIFICATION: cysteine residue {C2345}
cysteine residue {C2345}
MODIFICATION: cysteine residue {C2193}
PRECURSOR-FOR: coagulation factor VIIIa
PRODUCT: peptide
References
Fibrinolysis, Thrombosis, & Hemostasis: Concepts,
Perspectives, and Clinical Applications. S Sherry,
Lea & Febiger, Philadelphia, 1992, pg 81