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enzymatic reaction
A chemical reaction catalyzed by an enzyme. An enzymatic reaction consists of substrate(s), enzyme & product(s). The enzyme is unchanged by the reaction.
Properties
GENERAL: catalytic reaction
SPECIFIC: biochemical ligation
sialylation
active transport
protein phosphorylation
proteolytic cleavage
template-directed reaction
ENZYME: plasmin
COMPARTMENT: plasma
MOTIF: charge relay system
MOTIF: aspartate residue
histidine residue
serine residue
kringle domain
allosteric site
FOR-BINDING-OF: complement C1 inhibitor
STATE: active state
SUBSTRATE: fibronectin
CONFIGURATION: dimer
COMPARTMENT: plasma membrane
blood
MOTIF: signal sequence {1-31}
fibronectin type I domain or F1 module {50-90}
binding site
SITE: 52-272
FOR-BINDING-OF: fibrin
heparan sulfate
MOTIF: cysteine residue {C52}
MODIFICATION: cysteine residue {C78}
cysteine residue {C76}
MODIFICATION: cysteine residue {C87}
cysteine residue {C78}
MODIFICATION: cysteine residue {C52}
cysteine residue {C87}
MODIFICATION: cysteine residue {C76}
fibronectin type I domain or F1 module {95-228} (3)
fibronectin type I domain or F1 module {229-345}
MOTIF: cysteine residue {C231}
MODIFICATION: cysteine residue {C260}
cysteine residue {C258}
MODIFICATION: cysteine residue {C270}
cysteine residue {C260}
MODIFICATION: cysteine residue {C231}
cysteine residue {C270}
MODIFICATION: cysteine residue {C258}
fibronectin type I domain or F1 module {306-345}
binding site
SITE: 308-608
FOR-BINDING-OF: collagen
MOTIF: cysteine residue {C308}
MODIFICATION: cysteine residue {C335}
cysteine residue {C333}
MODIFICATION: cysteine residue {C342}
cysteine residue {C335}
MODIFICATION: cysteine residue {C308}
cysteine residue {C342}
MODIFICATION: cysteine residue {C333}
fibronectin type II domain or F2 module (2)
SITE: 355-403
FOR-BINDING-OF: collagen
MOTIF: cysteine residue {*1}
MODIFICATION: cysteine residue {*3}
cysteine residue {*2}
MODIFICATION: cysteine residue {*4}
cysteine residue {*3}
MODIFICATION: cysteine residue {*1}
cysteine residue {*4}
MODIFICATION: cysteine residue {*2}
N-glycosylation site {N430} (3)
fibronectin type I domain or F1 module {468-558} (3)
fibronectin type III domain or F3 module {607-898} (3)
DNA-binding motif
SITE: 907-1172
MOTIF: fibronectin type III domain or F3 module {908-1172} (3)
fibronectin type III domain or F3 module {1173-1265}
MOTIF: N-glycosylation site {N1244}
fibronectin type III domain or F3 module {1266-1720} (5)
MOTIF: RGD cell-attachment sequence
SITE: 1533-1536
FOR-BINDING-OF: integrin
binding site
SITE: 1721-1991
FOR-BINDING-OF: heparan sulfate
MOTIF: fibronectin type III domain or F3 module {1723-1991} (3)
Thr glycosylation site {T2064} (2)
fibronectin type III domain or F3 module {2100-2190}
MOTIF: N-glycosylation site {N2108}
fibronectin type I domain or F1 module {2204-2248}
binding site
SITE: 2206-2337
FOR-BINDING-OF: fibrin
MOTIF: cysteine residue {C2206}
MODIFICATION: cysteine residue {C2235}
cysteine residue {C2233}
MODIFICATION: cysteine residue {C2245}
cysteine residue {C2235}
MODIFICATION: cysteine residue {C2206}
cysteine residue {C2245}
MODIFICATION: cysteine residue {C2233}
fibronectin type I domain or F1 module {2249-2336} (2)
cysteine residue {C2367}
MODIFICATION: cysteine residue {C2371}
cysteine residue {C2371}
MODIFICATION: cysteine residue {C2367}
Ser phosphorylation site {S2384}
SECRETED-BY: endothelial cell
macrophage
synovial cell
hepatocyte
PRODUCT: peptide
References
Fibrinolysis, Thrombosis, & Hemostasis: Concepts,
Perspectives, and Clinical Applications. S Sherry,
Lea & Febiger, Philadelphia, 1992, pg 82