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enzymatic reaction
A chemical reaction catalyzed by an enzyme. An enzymatic reaction consists of substrate(s), enzyme & product(s). The enzyme is unchanged by the reaction.
Properties
GENERAL:
catalytic reaction
SPECIFIC:
biochemical ligation
sialylation
active transport
protein phosphorylation
proteolytic cleavage
template-directed reaction
ENZYME:
neprilysin
COMPARTMENT: plasma membrane
MOTIF: Stop-transfer sequence {16-23}
transmembrane domain {29-51}
cysteine residue {C57}
MODIFICATION: cysteine residue {C62}
cysteine residue {C62}
MODIFICATION: cysteine residue {C57}
cysteine residue {C80}
MODIFICATION: cysteine residue {C735}
cysteine residue {C88}
MODIFICATION: cysteine residue {C695}
binding site
SITE: 103-103
FOR-BINDING-OF: Substrate carboxyl
cysteine residue {C143}
MODIFICATION: cysteine residue {C411}
N-glycosylation site {N145}
cysteine residue {C234}
MODIFICATION: cysteine residue {C242}
cysteine residue {C242}
MODIFICATION: cysteine residue {C234}
N-glycosylation site {N285}
N-glycosylation site {N325}
cysteine residue {C411}
MODIFICATION: cysteine residue {C143}
Zn+2-binding site
SITE: 584-584
Zn+2-binding site
SITE: 588-588
aspartate residue {D591}
cysteine residue {C621}
MODIFICATION: cysteine residue {C747}
N-glycosylation site {N628}
Zn+2-binding site
SITE: 647-647
aspartate residue {D651}
cysteine residue {C695}
MODIFICATION: cysteine residue {C88}
cysteine residue {C735}
MODIFICATION: cysteine residue {C80}
cysteine residue {C747}
MODIFICATION: cysteine residue {C621}
STATE: active state
SUBSTRATE:
cholecystokinin
COMPARTMENT: extracellular compartment
SECRETED-BY: epithelial cell
WITHIN: intestine
MOTIF: sulfotyrosine site
MODIFICATION: sulfate
PRODUCT:
peptide
References
- Weber SJ, Louis RB, Trombley L, Bissette G, Davies P, Davis TP.
Metabolic half-life of somatostatin and peptidase activities
are altered in Alzheimer's disease.
J Gerontol. 1992 Jan;47(1):B18-25.
PMID: 1346149