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caspase-6; MCH-2 protein (CASP6, MCH2)
Function:
- role in the activation cascade of caspases responsible for apoptosis execution
- cleaves poly(ADP-ribose) polymerase & lamins in vitro
- cleaves DNA topoisomerase 1
- may participate in processing of amyloid precursor protein (APP) [2]
- overexpression promotes programmed cell death
- activation is suppressed by phosphorylation at Ser-257
- cleavages by caspase-3, caspase-8 or caspase-10 generate the two active subunits
- strict requirement for Asp at position P1 & has a preferred cleavage sequence of Val-Glu-His-Asp-|-
Structure:
- heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kD (p18) & a 11 kD (p11) subunit
- belongs to the peptidase C14 family
Compartment: cytoplasm
Alternative splicing: named isoforms=2
Interactions
molecular events
General
caspase; cysteinyl aspartate-specific proteinase; ICE/CED3 family protease
phosphoprotein
Properties
SIZE: entity length = 293 aa
MW = 33 kD
COMPARTMENT: cytoplasm
MOTIF: histidine residue {H121}
cysteine residue {C163}
Ser phosphorylation site {S257}
STATE: active state
Database Correlations
OMIM 601532
UniProt P55212
Pfam PF00656
Entrez Gene 839
KEGG correlations
ENZYME 3.4.22.59
References
- Martin SJ, Green DR.
Protease activation during apoptosis: death by a thousand cuts?
Cell. 1995 Aug 11;82(3):349-52. Review. No abstract available.
PMID: 7634323
- Rampon C, Jiang CH, Dong H, Tang YP, Lockhart DJ,
Schultz PG, Tsien JZ, Hu Y.
Effects of environmental enrichment on gene expression in
the brain.
Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12880-4.
PMID: 11070096
- UniProt :accession P55212