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enzymatic reaction
The CPP32/YAMA ICE family cysteine protease cleaves & inactivates poly ADP-ribose polymerase.
Properties
GENERAL: catalytic reaction
SPECIFIC: biochemical ligation
sialylation
active transport
protein phosphorylation
proteolytic cleavage
template-directed reaction
ENZYME: caspase-3
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S26}
histidine residue {H121}
cysteine residue {C163}
STATE: active state
SUBSTRATE: poly ADP-ribose polymerase
MOTIF: DNA-binding motif
SITE: 1-371
MOTIF: nuclear translocation signal {206-208}
<1/2SITE>
nuclear translocation signal {220-225}
<1/2SITE>
BRCA1 C-terminal (BRCT) motif
SITE: 384-460
automodification {372-523}
MOTIF: binding site (15)
SITE: 406-519
FOR-BINDING-OF: ADP ribose
cofactor-binding site [524-1013]
FOR-BINDING-OF: NAD
active site
SITE: 892
PRODUCT: peptide (SEVERAL)
References
- Martin SJ, Green DR.
Protease activation during apoptosis: death by a thousand cuts?
Cell. 1995 Aug 11;82(3):349-52. Review. No abstract available.
PMID: 7634323