cathepsin-L1 (major excreted protein, MEP, CTSL, CTSL1)

Function: - role in degradation of proteins in lysosomes - dimer of a heavy & a light chain linked by disulfide bonds - specificity close to that of papain - compared to cathepsin B, cathepsin L1 exhibits higher activity toward protein substrates - little activity on Z-Arg-Arg-NHMec - no peptidyl-dipeptidase activity Structure: belongs to the peptidase C1 family Compartment: lysosome Laboratory: - cathepsin L in serum/plasma

General

cathepsin cysteine proteinase; thiol proteinase

Properties

SIZE: entity length = 333 aa MW = 38 kD COMPARTMENT: lysosome STATE: active state MOTIF: signal sequence {1-17} cysteine residue {C135} MODIFICATION: cysteine residue {C178} cysteine residue {C138} active site MOTIF: cysteine residue cysteine residue {C169} MODIFICATION: cysteine residue {C211} cysteine residue {C178} MODIFICATION: cysteine residue {C135} cysteine residue {C211} MODIFICATION: cysteine residue {C169} N-glycosylation site {N221} cysteine residue {C269} MODIFICATION: cysteine residue {C-INTERCHAIN} histidine residue {H276} asparagine residue {N300}

Database Correlations

OMIM 116880 UniProt P07711 PFAM correlations Entrez Gene 1514 KEGG correlations ENZYME 3.4.22.15

References

UniProt :accession P07711