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enzymatic reaction
A chemical reaction catalyzed by an enzyme. An enzymatic reaction consists of substrate(s), enzyme & product(s). The enzyme is unchanged by the reaction.
Properties
GENERAL:
catalytic reaction
SPECIFIC:
biochemical ligation
sialylation
active transport
protein phosphorylation
proteolytic cleavage
template-directed reaction
ENZYME:
carboxypeptidase-E
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-25}
Zn+2-binding site
SITE: 114-114
Zn+2-binding site
SITE: 117-117
N-glycosylation site {N139}
Zn+2-binding site
SITE: 248-248
glutamate residue {E342}
N-glycosylation site {N390}
STATE: active state
SUBSTRATE:
somatostatin
COMPARTMENT: extracellular compartment
SECRETED-BY: delta cell (D cell)
WITHIN: islets of Langerhans
MOTIF: signal sequence {1-24}
cysteine residue {C105}
MODIFICATION: cysteine residue {C116}
cysteine residue {C116}
MODIFICATION: cysteine residue {C105}
PRODUCT:
peptide
References
- Weber SJ, Louis RB, Trombley L, Bissette G, Davies P, Davis TP.
Metabolic half-life of somatostatin and peptidase activities
are altered in Alzheimer's disease.
J Gerontol. 1992 Jan;47(1):B18-25.
PMID: 1346149