fodrin (non erythrocytic spectrin)

Function: - seems to be involved in secretion - interacts with calmodulin (Ca⁺²-dependent) - Ca⁺²-dependent movement of the cytoskeleton at the membrane (putative) - phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro (putative) - like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers Compartment: - cytoplasm, cytoskeleton - cell membrane - peripheral membrane protein; cytoplasmic side (putative)

General

calmodulin binding protein cytoskeletal protein membrane protein multisubunit protein PEST protein

Properties

COMPARTMENT: intracellular compartment CELL: neuron WITHIN: brain MOTIF: membrane region calmodulin binding site FOR-BINDING-OF: calmodulin PEST region SUBUNITS: alpha-fodrin MOTIF: spectrin repeat {10-42} spectrin repeat {44-147} spectrin repeat {149-253} spectrin repeat {255-359} spectrin repeat {361-465} spectrin repeat {467-571} spectrin repeat {573-676} spectrin repeat {678-782} spectrin repeat {784-888} spectrin repeat {890-955} src homology 3 [SH3] domain SITE: 967-1026 Ser phosphorylation site {S1029} Ser phosphorylation site {S1031} spectrin repeat {1062-1089} spectrin repeat {1091-1161} peptide motif {1176-1177} MOTIF: Tyr phosphorylation site {Y1176} spectrin repeat {1208-1231} MOTIF: Ser phosphorylation site {S1217} spectrin repeat {1233-1337} MOTIF: Ser phosphorylation site {S1323} spectrin repeat {1339-1443} spectrin repeat {1445-1549} spectrin repeat {1551-1656} spectrin repeat {1658-1762} spectrin repeat {1764-1868} spectrin repeat {1870-1974} spectrin repeat {1976-2081} spectrin repeat {2091-2195} spectrin repeat {2205-2310} EF hand SITE: 2323-2358 MOTIF: Ca+2-binding site SITE: 2336-2347 EF hand SITE: 2366-2401 MOTIF: Ca+2-binding site SITE: 2379-2390 EF hand SITE: 2404-2439 MOTIF: Tyr phosphorylation site {Y2423} beta-fodrin MOTIF: actin-binding site SITE: 1-275 FOR-BINDING-OF: F-actin MOTIF: calponin homology domain NAME: calponin homology domain SITE: 54-158 calponin homology domain NAME: calponin homology domain SITE: 173-275 spectrin repeat {276-384} spectrin repeat {385-498} spectrin repeat {499-608} spectrin repeat {609-714} spectrin repeat {715-819} spectrin repeat {820-925} spectrin repeat {926-1032} MOTIF: Thr phosphorylation site {T999} spectrin repeat {1033-1139} spectrin repeat {1140-1245} spectrin repeat {1246-1350} spectrin repeat {1351-1462} spectrin repeat {1463-1562} ANK2 interaction {1563-2093} MOTIF: spectrin repeat {1563-1668} spectrin repeat {1669-1775} spectrin repeat {1776-1881} Tyr phosphorylation site {Y1805} spectrin repeat {1882-1987} Ser phosphorylation site {S1918} spectrin repeat {1988-2133} MOTIF: Ser phosphorylation site {S2102} Ser phosphorylation site {S2115} Ser phosphorylation site {S2128} Ser phosphorylation site {S2138} Thr phosphorylation site {T2159} Ser phosphorylation site {S2160} Ser phosphorylation site {S2164} Ser phosphorylation site {S2165} Ser phosphorylation site {S2169} Thr phosphorylation site {T2187} Thr phosphorylation site {T2195} PH domain {2197-2307} Ser glycosylation site {S2324} Thr phosphorylation site {T2328} Ser phosphorylation site {S2341}

References

- Andrews BS. Is the WKS motif the tissue-factor binding site for coagulation factor VII? Trends Biochem Sci. 1991 Jan;16(1):31-6. Review. PMID: 2053135

Components

alpha-fodrin; spectrin alpha chain, brain; spectrin, non-erythroid alpha chain; alpha-II spectrin; fodrin alpha chain (SPTAN1, SPTA2) beta-fodrin; spectrin beta chain, brain 1; spectrin, non-erythroid beta chain 1; beta-II spectrin; Fodrin beta chain (SPTBN1, SPTB2)