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enzymatic reaction
A chemical reaction catalyzed by an enzyme. An enzymatic reaction consists of substrate(s), enzyme & product(s). The enzyme is unchanged by the reaction.
Properties
GENERAL: catalytic reaction
SPECIFIC: biochemical ligation
sialylation
active transport
protein phosphorylation
proteolytic cleavage
template-directed reaction
ENZYME: calpain-1
COMPARTMENT: intracellular compartment
CELL: neuron
WITHIN: brain
MOTIF: Ca+2-binding site
EFFECTOR-BOUND: Ca+2
STATE: active state
SUBSTRATE: fodrin
COMPARTMENT: intracellular compartment
CELL: neuron
WITHIN: brain
MOTIF: membrane region
calmodulin binding site
FOR-BINDING-OF: calmodulin
PEST region
PRODUCT: peptide
COMPARTMENT: intracellular compartment
CELL: neuron
WITHIN: brain
KINETIC-PARAMETERS: KI
KD
References
- Siman R, Noszek JC.
Excitatory amino acids activate calpain I and induce
structural protein breakdown in vivo.
Neuron. 1988 Jun;1(4):279-87.
PMID: 2856162