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enzymatic reaction
A chemical reaction catalyzed by an enzyme. An enzymatic reaction consists of substrate(s), enzyme & product(s). The enzyme is unchanged by the reaction.
Properties
GENERAL: catalytic reaction
SPECIFIC: biochemical ligation
sialylation
active transport
protein phosphorylation
proteolytic cleavage
template-directed reaction
ENZYME: calpain-1
COMPARTMENT: intracellular compartment
CELL: neuron
WITHIN: brain
ORGANISM: Homo sapiens
MOTIF: Ca+2-binding site
EFFECTOR-BOUND: Ca+2
STATE: active state
SUBSTRATE: neurofilament light polypeptide
COMPARTMENT: intracellular compartment
CELL: neuron
WITHIN: brain
ORGANISM: Homo sapiens
MOTIF: Head {2-92}
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Thr glycosylation site {T21}
Ser glycosylation site {S27}
Tyr phosphorylation site {Y43}
Ser phosphorylation site {S56}
Ser phosphorylation site {S67}
Rod {93-396}
MOTIF: Coil 1A {93-124}
Linker 1 {125-137}
Coil 1B {138-234}
Linker 12 {235-252}
Coil 2A {253-271}
Linker 2 {272-280}
Coil 2B {281-396}
epitope {381-391}
Tail {397-543}
MOTIF: Tail A {397-443}
Tyr phosphorylation site {Y424}
Tyr phosphorylation site {Y432}
Tail B {444-543}
Ser phosphorylation site {S472}
PRODUCT: peptide
COMPARTMENT: cytoplasm
CELL: neuron
WITHIN: brain
ORGANISM: Homo sapiens
References
- UI88337082
- Wang KK et al
Calmodulin-binding proteins as calpain substrates.
Biochem J 262:693 1989
PMID: 2556106
- Siman R, Noszek JC.
Excitatory amino acids activate calpain I and induce
structural protein breakdown in vivo.
Neuron. 1988 Jun;1(4):279-87.
PMID: 2856162