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calpain-1 or calcium-activated neutral protease-mu type
Calpain-1 is implicated in apoptosis induced by glucocorticoids, low level irradiation & inhibition of macromolecular synthesis [3].
Interactions
molecular events
General
calpain
pro apoptotic protein
Properties
COMPARTMENT: intracellular compartment
CELL: neuron
WITHIN: brain
ORGANISM: Homo sapiens
MOTIF: Ca+2-binding site
EFFECTOR-BOUND: Ca+2
STATE: active state
SUBUNITS: calpain-1 catalytic subunit
MOTIF: catalytic domain
SITE: 55-354
MOTIF: cysteine residue {C115}
histidine residue {H272}
asparagine residue {N296}
Domain III {355-526}
Linker {527-542}
Ca+2-binding site
EFFECTOR-BOUND: Ca+2
EF hand
SITE: 541-576
Domain IV {543-713}
MOTIF: EF hand
SITE: 585-618
Ca+2-binding site
SITE: 598-609
EF hand
SITE: 615-650
Ca+2-binding site
SITE: 628-639
EF hand
SITE: 680-714
calpain regulatory subunit
QUALITIES: PROTEIN-FRAGMENT
:PART C-TERMINAL
MOTIF: Ca+2-binding site
MISC-INFO: INHIBITOR = LEUPEPTIN
Kd [Ca+2] 4 UM
Database Correlations
Kegg hsa/hsa04210
References
- Choi 1988
- Siman and Noszek Neuron 1 279 1988
- Martin SJ, Green DR.
Protease activation during apoptosis: death by a thousand cuts?
Cell. 1995 Aug 11;82(3):349-52. Review. No abstract available.
PMID: 7634323
Components
calpain regulatory [small] subunit (CANP small subunit)
calpain-1 catalytic [large] subunit (calpain large polypeptide L1, CAPN1)