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enzymatic reaction
A chemical reaction catalyzed by an enzyme. An enzymatic reaction consists of substrate(s), enzyme & product(s). The enzyme is unchanged by the reaction.
Properties
GENERAL: catalytic reaction
SPECIFIC: biochemical ligation
sialylation
active transport
protein phosphorylation
proteolytic cleavage
template-directed reaction
ENZYME: calpain-1
COMPARTMENT: intracellular compartment
CELL: neuron
WITHIN: brain
ORGANISM: Homo sapiens
MOTIF: Ca+2-binding site
EFFECTOR-BOUND: Ca+2
STATE: active state
SUBSTRATE: neurofilament medium polypeptide
COMPARTMENT: intracellular compartment
CELL: neuron
WITHIN: brain
ORGANISM: Homo sapiens
MOTIF: Head {2-104}
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Thr glycosylation site {T47}
Rod {105-412}
MOTIF: Coil 1A {105-136}
Linker 1 {137-149}
Coil 1B {150-248}
Linker 12 {249-265}
Coil 2A {266-287}
Linker 2 {288-291}
Coil 2B {292-412}
Tyr phosphorylation site {Y320}
Tail {413-916}
MOTIF: Thr glycosylation site {T431}
Ser phosphorylation site {S511}
Ser phosphorylation site {S545}
Ser phosphorylation site {S553}
Ser phosphorylation site {S559}
consensus repeat {614-691} (6)
Ser phosphorylation site {S680}
Ser phosphorylation site {S685}
Ser phosphorylation site {S736}
Ser phosphorylation site {S783}
Ser phosphorylation site {S788}
Ser phosphorylation site {S837}
PRODUCT: peptide
COMPARTMENT: cytoplasm
CELL: neuron
WITHIN: brain
ORGANISM: Homo sapiens
References
- UI88337082
- Wang KK et al
Calmodulin-binding proteins as calpain substrates.
Biochem J 262:693 1989
PMID: 2556106
- Siman R, Noszek JC.
Excitatory amino acids activate calpain I and induce
structural protein breakdown in vivo.
Neuron. 1988 Jun;1(4):279-87.
PMID: 2856162