Search
enzymatic reaction
There are at least 2 populations of tau in the brain based on calpain_sensitivity, a calpain-sensitive form that is associated with microtubules and a calpain_resistant form that may represent another population of tau in the brain.
Properties
GENERAL: catalytic reaction
SPECIFIC: biochemical ligation
sialylation
active transport
protein phosphorylation
proteolytic cleavage
template-directed reaction
ENZYME: calpain
COMPARTMENT: cytoplasm
MOTIF: Ca+2-binding site
EFFECTOR-BOUND: Ca+2
STATE: active state
SUBSTRATE: microtubule-associated protein tau
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
lysine residue {24}
lysine residue {44}
Ser phosphorylation site {S46}
Thr phosphorylation site {T50}
lysine residue {67}
Thr phosphorylation site {T111}
lysine residue {381}
lysine residue {391}
lysine residue {392}
lysine residue {394}
lysine residue {465}
Thr phosphorylation site {T470}
Thr phosphorylation site {T492}
lysine residue {497}
Thr phosphorylation site {T498}
lysine residue {507}
Tyr phosphorylation site {Y514}
Ser phosphorylation site {S515}
Ser phosphorylation site {S516}
Ser phosphorylation site {S519}
Thr phosphorylation site {T522}
Thr phosphorylation site {T529}
Ser phosphorylation site {S531}
Thr phosphorylation site {T534}
lysine residue {541}
Thr phosphorylation site {T548}
Ser phosphorylation site {S552}
Ser phosphorylation site {S554}
lysine residue {557}
Tau/MAP {561-591}
MOTIF: lysine residue {571}
lysine residue {574}
Ser phosphorylation site {S579}
lysine residue {584}
lysine residue {591}
Tau/MAP {592-622}
MOTIF: lysine residue {607}
cysteine residue {C608}
MODIFICATION: cysteine residue {C639}
Ser phosphorylation site {S610}
lysine residue {611}
lysine residue {615}
Ser phosphorylation site {S622}
Tau/MAP {623-653}
MOTIF: lysine residue {628}
lysine residue {634}
lysine residue {638}
cysteine residue {C639}
MODIFICATION: cysteine residue {C608}
Ser phosphorylation site {S641}
lysine residue {648}
Tau/MAP {654-685}
MOTIF: lysine residue {657}
lysine residue {660}
Ser phosphorylation site {S673}
lysine residue {687}
lysine residue {692}
lysine residue {700}
lysine residue {702}
lysine residue {712}
Ser phosphorylation site {S713}
Ser phosphorylation site {S717}
Thr phosphorylation site {T720}
Ser phosphorylation site {S721}
Ser phosphorylation site {S726}
Ser phosphorylation site {S729}
Thr phosphorylation site {T731}
Ser phosphorylation site {S733}
Ser phosphorylation site {S739}
Thr phosphorylation site {T744}
lysine residue {755}
PRODUCT: peptide
QUALITIES: TAU-FRAGMENT
CALPAIN-PROTEOLYTIC-FRAGMENT
References
PMID: 89392068