Search
calpastatin
Function:
- cleaves & inactivates caspases, calpains
- role in postmortem tenderization of meat
- putative role in muscle protein degradation in living tissue
- phosphorylated
Structure:
- 4 inhibitory domains
- N-terminus is blocked
- belongs to the protease inhibitor I27 (calpastatin) family
Alternative splicing: named isoforms=4
Interactions
molecular events
General
cysteine protease inhibitor
oligomerizing protein
PEST protein
Properties
QUALITIES: PROTEIN-FRAGMENT
RETAINS-CALPAIN-BINDING-ACTIVITY
SIZE: entity length = 708 aa
MW = 77 kD
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S142}
Inhibitory {170-222}
MOTIF: Ser phosphorylation site {S222}
Ser phosphorylation site {S243}
Inhibitory {304-356}
Inhibitory {446-499}
Inhibitory {583-636}
INHIBITS: calpain
Database Correlations
OMIM 114090
UniProt P20810
Pfam PF00748
Entrez Gene 831
Kegg hsa:831
References
- Leist M et al
Four deaths and a funeral: from caspases to alternative
mechanisms.
Nat Rev Mol Cell Biol. 2001 Aug;2(8):589-98. Review.
PMID: 11483992
- UniProt :accession P20810
Component-of
molecular complex