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enzymatic reaction
Calpastatin is susceptible to proteolytic cleavage by calpain, with formation of small fragments which retain inhibitory activity
Properties
GENERAL: catalytic reaction
SPECIFIC: biochemical ligation
sialylation
active transport
protein phosphorylation
proteolytic cleavage
template-directed reaction
ENZYME: calpain
COMPARTMENT: cytoplasm
MOTIF: Ca+2-binding site
EFFECTOR-BOUND: Ca+2
STATE: active state
SUBSTRATE: calpastatin
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S142}
Inhibitory {170-222}
MOTIF: Ser phosphorylation site {S222}
Ser phosphorylation site {S243}
Inhibitory {304-356}
Inhibitory {446-499}
Inhibitory {583-636}
INHIBITS: calpain
PRODUCT: calpastatin
QUALITIES: PROTEIN-FRAGMENT
RETAINS-CALPAIN-BINDING-ACTIVITY
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S142}
Inhibitory {170-222}
MOTIF: Ser phosphorylation site {S222}
Ser phosphorylation site {S243}
Inhibitory {304-356}
Inhibitory {446-499}
Inhibitory {583-636}
INHIBITS: calpain
peptide
References
PMID: 90050514