enzymatic reaction

PEST motif-containing proteins are rapidly degraded by calpain. The PEST motif may sequester Ca+2 for calpain activation.

Properties

GENERAL: catalytic reaction SPECIFIC: biochemical ligation sialylation active transport protein phosphorylation proteolytic cleavage template-directed reaction ENZYME: calpain COMPARTMENT: cytoplasm MOTIF: Ca+2-binding site EFFECTOR-BOUND: Ca+2 STATE: active state SUBSTRATE: PEST protein* MOTIF: PEST region EFFECTOR-BOUND: Ca+2 PRODUCT: peptide

References

- Choi JY et al Molecular clonining and expression of a complementary DNA for inositol 1,4,5-triphosphate 3-kinase Science 248:64 1990 PMID: 2157285