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enzymatic reaction
Notch extracellular truncation (NEXT) is the physiologic substrate of gamma-secretase. NEXT cleavage occurs between gly1743 & val1744 of parent Notch-1 (S3). Cleavage serves to release the NOTCH1 intracellular domain (NICD) from the membrane. NICD then translocates to the nucleus, where it functions as a transcriptional activator in concert with CSL family members.
Properties
GENERAL: catalytic reaction
SPECIFIC: biochemical ligation
sialylation
active transport
protein phosphorylation
proteolytic cleavage
template-directed reaction
ENZYME: APP gamma-secretase
STATE: active state
MOTIF: active site
MOTIF: aspartate residue (2)
SUBSTRATE: Notch extracellular truncation
PRODUCT: Notch1 intracellular domain
peptide
References
- De Strooper B, Annaert W.
Where Notch and Wnt signaling meet. The presenilin hub.
J Cell Biol. 2001 Feb 19;152(4):F17-20.
PMID: 11266476