enzymatic reaction

Substrates for APP gamma-secretase include the APP C99 & C83 peptides. Cleavage of C99 results in formation of the A4 amyloid peptide, including A4/42 & A4/40 as well as other A4 peptides.

Properties

GENERAL: catalytic reaction SPECIFIC: biochemical ligation sialylation active transport protein phosphorylation proteolytic cleavage template-directed reaction ENZYME: APP gamma-secretase STATE: active state MOTIF: active site MOTIF: aspartate residue (2) SUBSTRATE: APP C99 peptide fragment PRODUCT: A4 amyloid peptide COMPARTMENT: extracellular compartment peptide

References

- Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001 Apr;81(2):741-66. Review. PMID: 11274343