enzymatic reaction

Substrates for APP gamma-secretase include the APP C99 & C83 peptides. Cleavage of C83 leads to peptides that are further catobolized & not related to Alzheimer pathology.

Properties

GENERAL: catalytic reaction SPECIFIC: biochemical ligation sialylation active transport protein phosphorylation proteolytic cleavage template-directed reaction ENZYME: APP gamma-secretase STATE: active state MOTIF: active site MOTIF: aspartate residue (2) SUBSTRATE: APP C83 peptide fragment PRODUCT: peptide

References

- Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001 Apr;81(2):741-66. Review. PMID: 11274343