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enzymatic reaction
A chemical reaction catalyzed by an enzyme. An enzymatic reaction consists of substrate(s), enzyme & product(s). The enzyme is unchanged by the reaction.
Properties
GENERAL: catalytic reaction
SPECIFIC: biochemical ligation
sialylation
active transport
protein phosphorylation
proteolytic cleavage
template-directed reaction
ENZYME: APP alpha-secretase
STATE: active state
MOTIF: active site
SUBSTRATE: APP-751
COMPARTMENT: plasma membrane
FORM: APP-751
MOTIF: cysteine-rich region
sulfotyrosine site
MODIFICATION: sulfate
Zn+2-binding site
acidic region
MOTIF: acidic residue (SEVERAL)
Kunitz-type serine protease inhibitor [KPI] domain {289-345}
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+X2}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+0}
FOR-BINDING-OF: serine protease
binding site
FOR-BINDING-OF: heparan sulfate
binding site
FOR-BINDING-OF: collagenase-4
MOTIF: O-glycosylation site
N-glycosylation site (2)
domain
MOTIF: proteolytic site
transmembrane domain {683-704}
Thr phosphorylation site {T710}
Ser phosphorylation site {S711}
binding site
FOR-BINDING-OF: Go protein
NPXY motif
NAME: NPXY motif
FOR-BINDING-OF: amyloid beta A4 protein-binding family B member 1
MOTIF-SEQUENCE: Asn-Pro-Thr-Tyr
PRECURSOR-FOR: protease nexin-2
COMPARTMENT: extracellular compartment
MOTIF: cysteine-rich region
sulfotyrosine site
MODIFICATION: sulfate
Zn+2-binding site
acidic region
MOTIF: acidic residue (SEVERAL)
Kunitz-type serine protease inhibitor [KPI] domain
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+X2}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+0}
FOR-BINDING-OF: serine protease
binding site
FOR-BINDING-OF: heparan sulfate
binding site
FOR-BINDING-OF: collagenase-4
MOTIF: O-glycosylation site
N-glycosylation site (2)
SECRETED-BY: neuron
platelet
INHIBITS: coagulation factor XIa
INHIBITS: collagenase-4
serine protease
PRODUCT: protease nexin-2
COMPARTMENT: extracellular compartment
MOTIF: cysteine-rich region
sulfotyrosine site
MODIFICATION: sulfate
Zn+2-binding site
acidic region
MOTIF: acidic residue (SEVERAL)
Kunitz-type serine protease inhibitor [KPI] domain
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+X2}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+0}
FOR-BINDING-OF: serine protease
binding site
FOR-BINDING-OF: heparan sulfate
binding site
FOR-BINDING-OF: collagenase-4
MOTIF: O-glycosylation site
N-glycosylation site (2)
SECRETED-BY: neuron
platelet
INHIBITS: coagulation factor XIa
peptide
COMPARTMENT: plasma membrane
MOTIF: transmembrane domain
NPXY motif
NAME: NPXY motif
S/T phosphorylation site (2)
TAG: APP-SECRETASE-1