enzymatic reaction

Reaction is at least an order of magnitude slower when vWf is bound to factor VIII.

Properties

GENERAL: catalytic reaction SPECIFIC: biochemical ligation sialylation active transport protein phosphorylation proteolytic cleavage template-directed reaction ENZYME: protein C, activated COMPARTMENT: plasma membrane CELL-REGION: apical region CELL: endothelial cell STATE: active state MOTIF: charge relay system MOTIF: aspartate residue histidine residue serine residue allosteric site EFFECTOR-BOUND: protein S SUBSTRATE: molecular complex PRODUCT: peptide peptide von Willebrand factor COMPARTMENT: plasma MOTIF: glycosylation site PEST region WKS motif binding site EFFECTOR-BOUND: coagulation factor VIII binding site FOR-BINDING-OF: glycoprotein IIB/IIIA binding site FOR-BINDING-OF: platelet glycoprotein 1b binding site FOR-BINDING-OF: collagen cysteine residue MODIFICATION: cysteine residue SECRETED-BY: endothelial cell TAG: COAGULATION-CASCADE-19