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protein C, activated

Function: - vitamin K-dependent serine protease - proteolytically inactivates coagulation factors: factor Va & factor VIIIa - stimulates fibrinolysis - activity is enhanced by protein S - cleavage of factor Va by activated protein C occurs at amino acid residue 506, the site of factor V Leiden mutation Expression: - plasma activity may be reduced as a result of acute thrombosis - anticoagulation lowers activity of protein C in plasma. Pharmacology: - recombinant activated protein C, see drotrecogin alpha (Xigris) Pathology: - see protein C deficiency

Interactions

molecular events

General

coagulation factor endogenous anticoagulant serine protease trypsin family

Properties

COMPARTMENT: plasma membrane CELL-REGION: apical region CELL: endothelial cell STATE: active state MOTIF: charge relay system MOTIF: aspartate residue histidine residue serine residue allosteric site EFFECTOR-BOUND: protein S allosteric site FOR-BINDING-OF: protein S

References

  1. Walker FJ, Fay PJ. Regulation of blood coagulation by the protein C system. FASEB J. 1992 May;6(8):2561-7. Review. PMID: 1317308
  2. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998