thrombin; coagulation factor IIa

Function: - vitamin K-dependent serine protease form by proteolysis of prothrombin - functions in blood homeostasis, inflammation & wound healing - proteolytically activates a) fibrinogen to fibrin b) factor V to factor Va c) factor VIII to factor VIIIa d) factor XIII to factor XIIIa e) in complex with thrombomodulin, protein C f) platelet factor IIa - selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin & release fibrinopeptide A & fibrinopeptide B

General

coagulation factor multisubunit protein serine protease trypsin family

Properties

SIZE: entity length = 308 aa COMPARTMENT: plasma STATE: active state SUBUNITS: protein subunit MOTIF: disulfide bridge protein subunit MOTIF: disulfide bridge allosteric site FOR-BINDING-OF: antithrombin-III allosteric site EFFECTOR-BOUND: thrombomodulin active site

Component-of

calcium chloride/fibrinogen/fibrinolytic inhibitor/thrombin fibrinogen concentrate/thrombin; fibrin sealant (Raplixa) fibrinogen/thrombin molecular complex thrombin/thromboplastin (Thrombinar)