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enzymatic reaction
A chemical reaction catalyzed by an enzyme. An enzymatic reaction consists of substrate(s), enzyme & product(s). The enzyme is unchanged by the reaction.
Properties
GENERAL: catalytic reaction
SPECIFIC: biochemical ligation
sialylation
active transport
protein phosphorylation
proteolytic cleavage
template-directed reaction
ENZYME: coagulation factor Va
COMPARTMENT: extracellular matrix
STATE: active state
MOTIF: active site
SUBSTRATE: prothrombin
COMPARTMENT: plasma
MOTIF: signal sequence {1-24}
Gla {44-89}
MOTIF: cysteine residue {C60}
MODIFICATION: cysteine residue {C65}
cysteine residue {C65}
MODIFICATION: cysteine residue {C60}
cysteine residue {C90}
MODIFICATION: cysteine residue {C103}
cysteine residue {C103}
MODIFICATION: cysteine residue {C90}
Kringle 1 {108-186}
MOTIF: cysteine residue {C108}
MODIFICATION: cysteine residue {C186}
N-glycosylation site {N121}
cysteine residue {C129}
MODIFICATION: cysteine residue {C169}
N-glycosylation site {N143}
cysteine residue {C157}
MODIFICATION: cysteine residue {C181}
cysteine residue {C169}
MODIFICATION: cysteine residue {C129}
cysteine residue {C181}
MODIFICATION: cysteine residue {C157}
cysteine residue {C186}
MODIFICATION: cysteine residue {C108}
proteolytic site {198-199}
Kringle 2 {213-291}
MOTIF: cysteine residue {C213}
MODIFICATION: cysteine residue {C291}
cysteine residue {C234}
MODIFICATION: cysteine residue {C274}
cysteine residue {C262}
MODIFICATION: cysteine residue {C286}
cysteine residue {C274}
MODIFICATION: cysteine residue {C234}
cysteine residue {C286}
MODIFICATION: cysteine residue {C262}
cysteine residue {C291}
MODIFICATION: cysteine residue {C213}
proteolytic site {327-328}
cysteine residue {C336}
MODIFICATION: cysteine residue {C-INTERCHAIN}
proteolytic site {363-364}
S1 domain {364-618}
MOTIF: cysteine residue {C391}
MODIFICATION: cysteine residue {C407}
histidine residue {H406}
cysteine residue {C407}
MODIFICATION: cysteine residue {C391}
N-glycosylation site {N416}
aspartate residue {D462}
cysteine residue {C536}
MODIFICATION: cysteine residue {C550}
cysteine residue {C550}
MODIFICATION: cysteine residue {C536}
binding site
SITE: 551-573
FOR-BINDING-OF: HIGH motif
cysteine residue {C564}
MODIFICATION: cysteine residue {C594}
serine residue {S568}
cysteine residue {C594}
MODIFICATION: cysteine residue {C564}
PRECURSOR-FOR: thrombin
COMPARTMENT: plasma
STATE: active state
PRODUCT: thrombin
COMPARTMENT: plasma
STATE: active state
peptide
COMPARTMENT: plasma
TAG: COAGULATION-CASCADE-11
CONTEXT: macromolecular complex
COMPONENTS: coagulation factor XIIa
STATE: active state
MOTIF: active site
MOTIF: serine residue
allosteric site
FOR-BINDING-OF: complement C1 inhibitor
kallikrein (SEVERAL)
MOTIF: charge relay system
MOTIF: aspartate residue
histidine residue
serine residue
STATE: active state
coagulation factor XIa
STATE: active state
MOTIF: charge relay system
MOTIF: aspartate residue
histidine residue
serine residue
allosteric site
FOR-BINDING-OF: complement C1 inhibitor
coagulation factor IXa
STATE: active state
MOTIF: charge relay system
MOTIF: aspartate residue
histidine residue
serine residue
allosteric site
EFFECTOR-BOUND: coagulation factor VIIIa
coagulation factor VIIIa
STATE: active state
coagulation factor VIIa
STATE: active state
MOTIF: charge relay system
MOTIF: aspartate residue
histidine residue
serine residue
coagulation factor Xa (SEVERAL)
STATE: active state
MOTIF: charge relay system
MOTIF: aspartate residue
histidine residue
serine residue
allosteric site
FOR-BINDING-OF: antithrombin-III
coagulation factor Va (SEVERAL)
STATE: active state
MOTIF: active site
thromboplastin
MOTIF: signal sequence {1-32}
peptide motif {46-48}
peptide motif {77-79}
cysteine residue {C81}
MODIFICATION: cysteine residue {C89}
cysteine residue {C89}
MODIFICATION: cysteine residue {C81}
N-glycosylation site {N156}
N-glycosylation site {N169}
peptide motif {190-192}
cysteine residue {C218}
MODIFICATION: cysteine residue {C241}
cysteine residue {C241}
MODIFICATION: cysteine residue {C218}
transmembrane domain {252-274}
cysteine residue {C277}
MODIFICATION: palmitate
COMPARTMENT: membrane
peptide
MOTIF: gamma-carboxyglutamate residue
NAME: gamma-carboxyglutamate residue
EFFECTOR-BOUND: Ca+2
high molecular weight [HMW] kininogen
INHIBITS: cysteine proteinase
MOTIF: cysteine-rich region {N-TERMINAL} (3)
FOR-BINDING-OF: cysteine proteinase
proteolytic site
glycosylation site
WKS motif
PRECURSOR-FOR: bradykinin
collagen
COMPARTMENT: extracellular matrix