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Alzheimer's disease start hypothetical AD pathology events Evidence that A4 deposition initiates AD pathology Evidence from familial forms of AD 1 Evidence from familial forms of AD 2 Alzheimer's disease conclusions Neuropathologic changes in Alzheimer's disease Neurochemical changes in Alzheimer's disease 1 Neurochemical changes in Alzheimer's disease 2 Neurochemical changes in Alzheimer's disease 3 Neurofibrillary tangles Neuritic plaques Laboratory Evaluation of Dementia