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N-terminal acetyltransferase complex ARD1 subunit homolog A (ARD1A, ARD1, TE2, NAA10)
Function:
- in complex with NARG1, displays alpha (N-terminal) acetyltransferase activity
- without NARG1, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation
- cleaved by caspases during apoptosis
- interacts with HIF1A (via its ODD domain); the interaction increases HIF1A protein stability during normoxia, & downregulates it when induced by hypoxia
- interacts with NARG1, NAT13 & with the ribosome
Structure:
- belongs to the acetyltransferase family, ARD1 subfamily
- contains 1 N-acetyltransferase domain
Compartment:
- cytoplasm, nucleus
- also present in the free cytosolic & cytoskeleton-bound polysomes
Expression: ubiquitous
Related
GTP-binding protein ARD1; ADP-ribosylation factor domain-containing protein 1; tripartite motif-containing protein 23; RING finger protein 46 (TRIM23, ARD1, ARFD1, RNF46)
General
acetyltransferase
phosphoprotein
protein subunit
Properties
SIZE: entity length = 235 aa
MW = 26 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: N-acetyltransferase {1-152}
MOTIF: NARG1 interaction {1-58}
Ser phosphorylation site {S182}
Ser phosphorylation site {S186}
Ser phosphorylation site {S205}
Database Correlations
OMIM 300013
UniProt P41227
Pfam PF00583
Entrez Gene 8260
Kegg hsa:8260
ENZYME 2.3.1.88
References
- UniProt :accession P41227
- Jeong JW et al
Regulation and destabilization of HIF-1alpha by ARD1-mediated
acetylation.
Cell. 2002 Nov 27;111(5):709-20.
PMID: 12464182
- Arnesen T et al
Identification and characterization of the human ARD1-NATH
protein acetyltransferase complex.
Biochem J. 2005 Mar 15;386(Pt 3):433-43
PMID: 15496142
Component-of
CASK/TRB1/TSPYL2 transcriptional complex