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DNA-binding protein RFX5; regulatory factor X 5 (RFX5)
Function:
- component of regulatory factor X (RFX)
- activates transcription from class II MHC promoters
- recognizes X-boxes
- mediates cooperative binding between RFX & NF-Y
- phosphorylated
Structure:
- the N-terminus is required for its association with RFXANK & RFXAP, for assembly of the RFX complex, & for binding of this the RFX complex to its X box target site in the MHC-II promoter
- the C-terminus mediates cooperative binding between the RFX complex & NF-Y
- belongs to the RFX family
- contains 1 H-T-H motif winged-type DNA-binding domain
Compartment: nucleus
Expression: ubiquitous
Pathology:
- defects in RFX5 are a cause of bare lymphocyte syndrome-2
General
DNA-binding protein
protein subunit
Properties
SIZE: entity length = 616 aa
MW = 65 kD
MOTIF: DNA-binding motif
SITE: 92-168
MOTIF: DNA-binding motif
SITE: 95-167
Database Correlations
OMIM correlations
UniProt P48382
Pfam PF02257
Entrez Gene 5993
Kegg hsa:5993
References
- UniProt :accession P48382
- RFX5base; Note: RFX5 mutation db
http://bioinf.uta.fi/RFX5base/
Component-of
regulatory factor X (RFX)