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histone H4 (HIST1H4A, H4/A, H4FA, HIST1H4B, H4/I, H4FI, HIST1H4C, H4/G, H4FG, HIST1H4D, H4/B, H4FB, HIST1H4E, H4/J, H4FJ, HIST1H4F, H4/C, H4FC, HIST1H4H, H4/H, H4FH, HIST1H4I, H4/M, H4FM, HIST1H4J, H4/E, H4FE, HIST1H4K, H4/D, H4FD, HIST1H4L, H4/K, H4FK, HIST2H4A, H4/N, H4F2, H4FN, HIST2H4, HIST2H4B, H4/O, H4FO, HIST4H4)
Function:
- core component of nucleosome
- acetylation at Lys-6, Lys-9, Lys-13 & Lys-17 occurs in coding regions of the genome but not in heterochromatin
- citrullination at Arg-4 by PADI4 impairs methylation
- monomethylation at Arg-4 by PRMT1 favors acetylation at Lys-9 & Lys-13
- demethylation by JMJD6
- monomethylated, dimethylated or trimethylated at Lys-21
- monomethylation by SET8
- trimethylation by SUV420H1 & SUV420H2 induces gene silencing
- ubiquitinated by the CUL4-DDB-RBX1 complex in response to ultraviolet irradiation; this may weaken the interaction between histones & DNA & facilitate DNA accessibility to DNA repair proteins
- sumoylation is associated with transcriptional repression
Structure: belongs to the histone H4 family
Compartment: nucleus
General
histone
phosphoprotein
Properties
QUANTITY: 2
SIZE: entity length = 103 aa
MW = 11 kD
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S2}
DNA-binding motif
SITE: 17-21
Ser phosphorylation site {S48}
Tyr phosphorylation site {Y52}
Tyr phosphorylation site {Y89}
Database Correlations
OMIM correlations
UniProt P62805
Pfam PF00125
LOCUS-LINK correlations
KEGG correlations
References
- UniProt :accession P62805
Component-of
nucleosome