histone-H2A

Function: 1) core component of nucleosome 2) the nucleosome is a histone octamer containing 2 molecules each of H2A, H2B, H3 & H4 assembled in one H3-H4 heterotetramer & 2 H2A-H2B heterodimers 3) chromatin-associated form is phosphorylated on Thr-120 during mitosis 4) monoubiquitination of Lys gives a specific tag for epigenetic transcriptional repression in different histone H2A proteins 5) ubiquitinated H2A is enriched in inactive X chromosome chromatin 6) ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3

Properties

QUANTITY: 2 MOTIF: binding site FOR-BINDING-OF: ubiquitin