polyhomeotic-like protein 3 (hPH3, homolog of polyhomeotic 3, early development regulatory protein 3, PHC3, EDR3, PH3)

Function: - component of the Polycomb group PRC1 complex - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - contains 1 FCS-type zinc finger. - contains 1 SAM domain (sterile alpha motif) Compartment: nucleus

General

phosphoprotein zinc finger protein

Properties

SIZE: MW = 106 kD entity length = 983 aa COMPARTMENT: cell nucleus MOTIF: threonine-rich region {19-26} MOTIF: threonine residue (SEVERAL) serine-rich region {89-287} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S229} Ser phosphorylation site {S263} glutamine-rich region {324-539} MOTIF: glutamine residue (SEVERAL) proline-rich region SITE: 346-670 MOTIF: proline residue (SEVERAL) Thr phosphorylation site {T609} Ser phosphorylation site {S616} HD1 {691-720} Zinc finger NAME: Zinc finger SITE: 776-810 EFFECTOR-BOUND: Zn+2 sterile alpha motif NAME: sterile alpha motif SITE: 919-983

Database Correlations

UniProt Q8NDX5 Pfam PF00536

References

UniProt :accession Q8NDX5