heterogeneous nuclear ribonucleoprotein Q (hnRNP-Q, synaptotagmin-binding cytoplasmic RNA-interacting protein, glycine- & tyrosine-rich RNA-binding protein, GRY-RBP, NS1-associated protein 1, SYNCRIP, HNRPQ, NSAP1)

Function: 1) implicated in mRNA processing mechanisms 2) translationally coupled mRNA turnover 3) component of spliceosome C complex 4) domain containing 8 Arg-Gly-Gly repeats may be involved in RNA-binding & protein-protein interactions 5) phosphorylated on Tyr in vivo 6) membrane-bound form found in microsomes is phosphorylated in vitro by insulin receptor tyrosine kinase (INSR); phosphorylation inhibited upon binding to RNA 7) cytoplasmic form is poorly phosphorylated Structure: - domain containing 8 Arg-Gly-Gly repeats may be involved in RNA-binding & protein-protein interactions Compartment: - microsome, nucleus - Tyr phosphorylated form bound to RNA is found in microsomes Alternative splicing: named isoforms=5 Expression: - ubiquitously expressed - expressed in heart, brain, pancreas, placenta, spleen, lung, liver, skeletal muscle, kidney, thymus, prostate, uterus, small intestine, colon, peripheral blood, testis

Properties

SIZE: MW = 70 kD entity length = 623 aa MOTIF: RNP motif NAME: RNP motif SITE: 162-241 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 243-325 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RRM 3 {338-408} MOTIF: Tyr phosphorylation site {Y373} binding site SITE: 400-561 FOR-BINDING-OF: apo B mRNA-editing protein MOTIF: 8 RGG repeats {448-559} MOTIF: 3 YYGY repeats {460-488} binding site SITE: 518-549 FOR-BINDING-OF: SMN complex nuclear translocation signal {564-578}

Database Correlations

UniProt O60506 Pfam PF00076

References

UniProt :accession O60506