small nuclear ribonucleoprotein Sm D1; Sm-D1; Sm-D autoantigen; snRNP core protein D1 (SNRPD1)

Function: - may act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through nonspecific electrostatic contacts with RNA - methylated on Arg by PRMT5 & PRMT7 - methylation is required for assembly & biogenesis of snRNPs - identified in the spliceosome C complex - component of the U11/U12 snRNPs that are part of the U12-type spliceosome Structure: belongs to the snRNP core protein family Compartment: nucleus Pathology: - anti Sm antibodies are found in patients with systemic lupus erythematosus

Properties

SIZE: entity length = 119 aa MW = 13 kD COMPARTMENT: cell nucleus MOTIF: lysine-rich region {86-119} MOTIF: lysine residue (SEVERAL)

Database Correlations

OMIM 601063 UniProt P62314 Pfam PF01423 Entrez Gene 6632 Kegg hsa:6632 ENZYME

References

UniProt :accession P13641