splicing factor 3B subunit 3 (spliceosome associated protein 130, SAP 130, SF3b130, pre-mRNA splicing factor SF3b 130 kD subunit, SF3B4)

Function: - subunit of the splicing factor SF3B - identified in the spliceosome C complex - SF3B associates with the splicing factor SF3A & a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP) - SF3B2 interacts directly with SF3B4 - interacts with HIV-1 Vpr - phosphorylated upon DNA damage, probably by ATM or ATR Structure: contains 1 SAP domain Compartment: nucleus (putative)

General

phosphoprotein protein subunit splicing factor; snRNP-associated protein

Properties

SIZE: MW = 136 kD entity length = 1217 aa COMPARTMENT: cell nucleus MOTIF: RNA-binding motif FOR-BINDING-OF: ribonucleic acid phosphorylation site

Database Correlations

OMIM 605592 UniProt Q15393 Pfam PF03178

References

UniProt :accession Q15393