splicing factor 3B subunit 1 (spliceosome associated protein 155, SAP 155, SF3b155, pre-mRNA splicing factor SF3b 155 kD subunit, SF3B1)

Function: - subunit of the splicing factor SF3B - identified in the spliceosome C complex - SF3B1 interacts directly with the splicing factor U2AF - phosphorylated form interacts with PPP1R8 - phosphorylation occurs concomitantly with the splicing catalytic steps. - phosphorylation on Thr-244, Thr-248 & Thr-313 by cyclin-dependent kinases promotes interaction with PPP1R8 during mitosis Structure: - belongs to the SF3B1 family - contains 11 HEAT repeats Compartment: - nucleus speckle - during mitosis, transiently dispersed from the nuclear speckles to the cytoplasm

General

phosphoprotein protein subunit splicing factor; snRNP-associated protein

Properties

SIZE: entity length = 1304 aa MW = 146 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: Thr phosphorylation site {T142} Thr phosphorylation site {T207} Thr phosphorylation site {T211} PPP1R8 interaction {223-491} MOTIF: Thr phosphorylation site {T223} Thr phosphorylation site {T227} Thr phosphorylation site {T235} Thr phosphorylation site {T244} Thr phosphorylation site {T248} Thr phosphorylation site {T267} Thr phosphorylation site {T296} Thr phosphorylation site {T299} Thr phosphorylation site {T313} Thr phosphorylation site {T316} Thr phosphorylation site {T326} Thr phosphorylation site {T328} Ser phosphorylation site {S344} Thr phosphorylation site {T350} Thr phosphorylation site {T354} HEAT repeat {529-568} HEAT repeat {569-603} HEAT repeat {604-641} HEAT repeat {643-677} HEAT repeat {680-718} HEAT repeat {763-801} HEAT repeat {843-881} HEAT repeat {1010-1048} HEAT repeat {1052-1090} HEAT repeat {1122-1160} HEAT repeat {1163-1201}

Database Correlations

OMIM 605590 UniProt O75533 PFAM correlations

References

UniProt :accession O75533