splicing factor 3A subunit 1 (spliceosome associated protein 114, SAP 114, SF3a120, SF3A1)

Function: - subunit of the splicing factor SF3A - identified in the spliceosome C complex - interacts with SF3A3 - phosphorylated upon DNA damage, probably by ATM or ATR Structure: - contains 2 SURP motif repeats - contains 1 ubiquitin-like domain Compartment: nucleus (putative) Expression: ubiquitously expressed

General

protein subunit splicing factor; snRNP-associated protein

Properties

SIZE: entity length = 793 aa MW = 89 kD COMPARTMENT: cell nucleus MOTIF: proline-rich region SITE: 10-16 MOTIF: proline residue (SEVERAL) SURP {52-94} glutamine-rich region {118-122} MOTIF: glutamine residue (SEVERAL) Thr phosphorylation site {T124} SURP {166-208} glutamate-rich region {260-267} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S320} Ser phosphorylation site {S329} Ser phosphorylation site {S359} proline-rich region SITE: 369-372 MOTIF: proline residue (SEVERAL) Tyr phosphorylation site {Y456} proline-rich region SITE: 557-560 MOTIF: proline residue (SEVERAL) proline-rich region SITE: 672-675 MOTIF: proline residue (SEVERAL) Ubiquitin-like {707-793} MOTIF: Tyr phosphorylation site {Y759}

Database Correlations

OMIM 605595 UniProt Q15459 PFAM correlations Kegg hsa:1029

References

UniProt :accession Q15459