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peptidyl-prolyl cis-trans isomerase-like 3 (PPIase, Rotamase, cyclophilin-like protein PPIL3, cyclophilin J, CyPJ, PPIL3)
Function:
- accelerates folding of proteins
- catalyzes cis-trans isomerization of proline imidic peptide bonds in oligopeptides
- may be involved in pre-mRNA splicing
- identified in the spliceosome C complex
Structure:
- belongs to the cyclophilin-type PPIase family, PPIL3 subfamily
- contains 1 PPIase cyclophilin-type domain
Alternative splicing: named isoforms=2
Expression:
- ubiquitous
- detected at low levels
General
cyclophilin
Properties
SIZE: MW = 18 kD
entity length = 161 aa
MOTIF: active site
SITE: 1-154
Database Correlations
UniProt Q9H2H8
Pfam PF00160
ENZYME 5.2.1.8
References
UniProt :accession Q9H2H8
Component-of
spliceosome C complex