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peptidyl-prolyl cis-trans isomerase-like 3 (PPIase, Rotamase, cyclophilin-like protein PPIL3, cyclophilin J, CyPJ, PPIL3)

Function: - accelerates folding of proteins - catalyzes cis-trans isomerization of proline imidic peptide bonds in oligopeptides - may be involved in pre-mRNA splicing - identified in the spliceosome C complex Structure: - belongs to the cyclophilin-type PPIase family, PPIL3 subfamily - contains 1 PPIase cyclophilin-type domain Alternative splicing: named isoforms=2 Expression: - ubiquitous - detected at low levels

General

cyclophilin

Properties

SIZE: MW = 18 kD entity length = 161 aa MOTIF: active site SITE: 1-154

Database Correlations

UniProt Q9H2H8 Pfam PF00160 ENZYME 5.2.1.8

References

UniProt :accession Q9H2H8

Component-of

spliceosome C complex