Pre-mRNA-splicing factor ISY1 homolog (ISY1 KIAA1160)

Function: - role in pre-mRNA splicing (potential) - identified in the spliceosome C complex - phosphorylated upon DNA damage, probably by ATM or ATR Structure: belongs to the ISY1 family Compartment: nucleus Alternative splicing: named isoforms=3

General

phosphoprotein splicing factor; snRNP-associated protein

Properties

SIZE: MW = 38 kD entity length = 331 aa COMPARTMENT: cell nucleus MOTIF: glutamate-rich region {201-211} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S222} Ser phosphorylation site {S227} Ser phosphorylation site {S247}

Database Correlations

UniProt Q9ULR0 Pfam PF06246

References

UniProt :accession Q9ULR0