heterogeneous nuclear ribonucleoprotein R; hnRNP R (HNRNPR, HNRPR)

Function: - component of ribonucleosomes - like other hnRNPs, plays role in processing of precursor mRNA in the nucleus - identified in the spliceosome C complex Structure: contains 3 RRM domains (RNA recognition motifs) Compartment: - nucleus, nucleoplasm, cytoplasm - localized in cytoplasmic mRNP granules containing untranslated mRNAs Alternative splicing: named isoforms=2

General

heterogeneous nuclear ribonucleoprotein (hnRNP) RNA-binding protein

Properties

SIZE: entity length = 633 aa MW = 71 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acidic region {2-153} MOTIF: acidic residue (SEVERAL) acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl RNP motif NAME: RNP motif SITE: 165-244 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 246-328 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 341-411 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif nuclear translocation signal {412-418} binding site SITE: 447-567 FOR-BINDING-OF: ribonucleic acid MOTIF: domain {462-497} consensus repeat {462-471} consensus repeat {472-482} consensus repeat {488-497} glutamine-rich region {579-633} MOTIF: glutamine residue (SEVERAL)

Database Correlations

OMIM 607201 UniProt O43390 Pfam PF00076 Entrez Gene 10236 Kegg hsa:10236

References

UniProt :accession O43390