ATP-dependent RNA helicase DHX8; DEAH box protein 8; RNA helicase HRH1 (DHX8 DDX8)

Function: - facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome - identified in the spliceosome C complex - interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation Structure: - the RS domain confers a nuclear localization signal, & appears to facilitate the interaction with the spliceosome - belongs to the DEAD box helicase family, DEAH subfamily, DDX8/PRP22 sub-subfamily - contains 1 helicase ATP-binding domain - contains 1 helicase C-terminal domain - contains 1 S1 motif domain Compartment: nucleus

General

DEAH box ATP-dependent helicase phosphoprotein

Properties

SIZE: entity length = 1220 aa MW = 139 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl lysine-rich region {172-175} MOTIF: lysine residue (SEVERAL) arginine/serine-rich region (RS domain) {176-228} MOTIF: serine residue (SEVERAL) arginine residue (SEVERAL) Ser phosphorylation site {S224} Ser phosphorylation site {S228} Ser phosphorylation site {S230} S1 domain {265-336} Ser phosphorylation site {S395} Thr phosphorylation site {T554} Ser phosphorylation site {S557} helicase NAME: helicase SITE: 575-738 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 588-595 DEAD/H box NAME: DEAD/H box SITE: 685-688 Helicase C-terminal {756-936}

Database Correlations

OMIM 600396 UniProt Q14562 PFAM correlations Entrez Gene 1659 Kegg hsa:1659 ENZYME 3.6.4.13

References

UniProt :accession Q14562