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crooked neck-like protein 1 (crooked neck homolog, hCrn, CRNKL1, CRN, CGI-201, MSTP021)
Function:
- role in pre-mRNA splicing process
- identified in the spliceosome C complex (isoform 2 predominant)
Structure:
- belongs to the crooked-neck family
- contains 17 HAT repeats
Compartment:
- nuclear speckle, cytoplasm
- colocalizes with core spliceosomal snRNP proteins
- diffusely expressed in cytoplasm
Alternative splicing: named isoforms=5
Expression:
- widely expressed
- highly expressed in testis
- not expressed in brain & lung
Note:
- may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
General
protein subunit
Properties
SIZE: MW = 100 kD
entity length = 848 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: proline-rich region
SITE: 207-210
MOTIF: proline residue (SEVERAL)
HAT {222-254}
HAT {256-288}
HAT {290-322}
HAT {324-355}
HAT {357-388}
HAT {390-425}
HAT {427-461}
HAT {471-503}
HAT {505-539}
HAT {549-585}
HAT {587-618}
HAT {620-652}
HAT {654-688}
HAT {690-721}
HAT {726-767}
HAT {769-807}
HAT {809-834}
Database Correlations
UniProt Q9BZJ0
Pfam PF02184
References
UniProt :accession Q9BZJ0
Component-of
spliceosome C complex