nuclear cap binding protein subunit 2 (20 kD nuclear cap binding protein, NCBP 20 kD subunit, CBP20, NCBP interacting protein 1, NIP1)

Function: 1) involved in mediating U snRNA export from the nucleus 2) binds to 5'capped mRNA 3) heterodimer with NCBP1. 4) component of nuclear mRNA cap-binding protein 5) component of exon junction complex 6) phosphorylated upon DNA damage, probably by ATM or ATR Structure: - belongs to the RRM NCBP2 family - contains 1 RRM domain (RNA recognition motif) Compartment: nucleus

General

phosphoprotein protein subunit

Properties

SIZE: entity length = 156 aa MW = 18 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S13} Ser phosphorylation site {S18} RNP motif NAME: RNP motif SITE: 40-118 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif

Database Correlations

OMIM 605133 UniProt P52298 Pfam PF00076

References

UniProt :accession P52298