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GTP-binding nuclear protein Ran; GTPase Ran; Ras-related nuclear protein; Ras-like protein TC4; androgen receptor-associated protein 24; spi1 protein (RAN, ARA24, OK/SW-cl81)
Function:
- nucleocytoplasmic transport
a) import of proteins into nucleus
b) export of RNA from nucleus
- chromatin condensation
- cell cycle control
- enhances androgen receptor (AR) mediated transactivation;
a) interacts with AR N-terminal poly-Gln region
b) interaction with AR is inversely correlated with the poly-Gln length
- forms a complex with CHC1
- part of a complex consisting of RANBP9, Ran, DYRK1B & COPS5
- found in a nuclear export complex with RANBP3 & XPO1
- component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN & XPO1
- found in a trimeric export complex with SNUPN, Ran & XPO1
- interacts with RANBP10
Structure:
- monomer
- N-terminus is blocked
- belongs to the small GTPase superfamily, Ran family
Compartment:
- nucleus,cytoplasm. melanosome
- becomes dispersed throughout the cytoplasm during mitosis
- in melanosome fractions from stage 1 to stage 4
Expression: expressed in a variety of tissues
Pathology:
- in HIV-1 infection, found in a complex with HIV-1 Rev, RNAs containing a Rev response element (RRE) & XPO1
- found in a complex with HTLV-1 Rex, RANBP3 & XPO1
General
nuclear protein
ran subfamily protein
Properties
SIZE: entity length = 216 aa
MW = 24 kD
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
GTP-binding site
SITE: 17-24
GTP-binding site
SITE: 65-69
GTP-binding site
SITE: 122-125
Tyr phosphorylation site {Y147}
Tyr phosphorylation site {Y155}
Database Correlations
OMIM 601179
UniProt P62826
Pfam PF00071
Entrez Gene 5901
Kegg hsa:5901
References
- Kahn RA, Der CJ, Bokoch GM.
The ras superfamily of GTP-binding proteins: guidelines on
nomenclature.
FASEB J. 1992 May;6(8):2512-3.
PMID: 1592203
- Scheffzek K, Klebe C, Fritz-Wolf K, Kabsch W, Wittinghofer A.
Crystal structure of the nuclear Ras-related protein Ran in
its GDP-bound form.
Nature. 1995 Mar 23;374(6520):378-81.
PMID: 7885480
(crystal structure)
- UniProt :accession P17080
Component-of
U snRNA export complex