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phosphatase-2A B subunit

Function: - several forms of phosphatase 2A B subunit encoded by separate genes are found complexed with a single catalytic (PP2A-cat) & A subunit. - at least one form is specific for the nervous system [1] - the PP2A-B subunit appears to suppress the activity of PP2A - since ceramide activates heterotrimeric PP2A, but not PP2A-catalytic monomer or PP2A-cat/PP2A-A hetero-dimer, an allosteric site for binding of ceramide is included as a motif for the B subunit - binding of ceramide is suggested to inhibit PP2A-B inhibition of PP2A

Related

ceramide

General

protein subunit

Properties

MOTIF: binding site FOR-BINDING-OF: ceramide

References

  1. Goedert M. Tau protein and the neurofibrillary pathology of Alzheimer's disease. Trends Neurosci. 1993 Nov;16(11):460-5. Review. PMID: 7507619
  2. Hannun YA, Obeid LM. Ceramide: an intracellular signal for apoptosis. Trends Biochem Sci. 1995 Feb;20(2):73-7. Review. PMID: 7701566

Component-of

phosphatase-2A (ceramide-activated protein phosphatase)